Showing posts written by Biotage
Antibodies are indispensable tools that are used in a variety of research applications, diagnostics, and therapeutics. Often, these applications require purified antibodies which means that the antibo...
Sometimes we find ourselves having to make decisions fast, and act even faster - especially in situations like the one we live in today, where there is a high degree of uncertainty. In this kind of si...
In this blog, I will address something that is fundamental to years of classic process chemistry techniques. First disclaimer is that the pharma industry uses recrystallization for several purposes, n...
Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question I usually receive, relates to ho...
It’s engrained in our minds and psyche, from earliest school days and exposures to science that heating a reaction speeds it up. Later, we learn some more of the details, that by increasing the temper...
Another excellent question we received following seminars and presentations relates to the function and activity of metal scavengers. IUPAC nomenclature rules combined with various naming systems and ...
Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive ...
There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods...
Removing palladium has become more and more difficult for a number of reasons. Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducin...
Whether for pharma, fine chemical, agrochemical, electronic or natural product research, in recent years, there has been increasing pressure to achieve and deliver higher purity products. Chemical pro...