Showing posts written by Biotage
Introduction The diverse nature of the samples in food safety testing applications adds complexity making method standardisation challenging. However, default methodology for solid matrix pesticide an...
Introduction ISOLUTE® EPH SPE cartridges and associated methodologies have been optimized to efficiently fractionate EPHs into aliphatic and polycyclic aromatic (PAH) fractions (C8–C40 aliphatics, C10...
Summary A novel feature that inserts an isocratic hold into a linear gradient when a compound elutes can improve the separation of partially co-eluting compounds, simplifying flash chromatography meth...
Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) are biomarkers for neuroblastoma and catecholamine secreting tumours. We present ...
Urine is a very useful matrix in forensic laboratories, because it is easy to collect and can help determine if a drug has been used recently. There are many viable sample preparation options for urin...
Compliance with GMP is a necessary condition for drug authorization however the scrutiny that it demands can pose local engineering and chemistry issues because process chemists are under increasing p...
Oral fluid represents a complex, heterogeneous biological fluid primarily produced by the parotid, submandibular, and sublingual salivary glands. Together, these glands make the majority of saliva, wh...
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. At Biotage...
Introduction Taking chemistry from the bench to the market efficiently requires optimized synthetic and purification routes. Choosing the right reaction solvent and purification method will help achie...
The screening for elevated levels of methylmalonic acid (MMA) in serum is commonly used as a clinical diagnostic indicator of Cobalamin (Vitamin B12) deficiency in humans. MMA is commonly analyzed usi...