Showing posts written by Bob Bickler
On December 6th, 2018, Bob Bickler, Senior Technical Specialist, recorded a webinar on Inspiring Productivity with Modern Flash Chromatography. To learn more, read the description below as well as wat...
For many chemists, flash chromatography with UV-triggered fractionation is part of their everyday workflow. Prior to flash chromatography, the reaction mixtures are either analyzed by TLC, analyzed by...
Organic reactions are generally inefficient, which means that crude reaction mixtures require work-up and purification to remove by-products and unreacted starting materials and/or catalysts. The goal...
First, join me on a flashback to my past as a discovery chemist just fresh out of grad school and eager to make a difference in pharmaceutical research. I was advised by my boss to model my behavior a...
I am often asked why reversed-phase TLC data does not translate well to reversed-phase flash column chromatography. There are several reasons for this and in this post I will attempt to explain the ch...
Method transfer from reversed-phase TLC (thin layer chromatography) to reversed-phase flash column chromatography can be very challenging. Because of this, I often recommend using HPLC for reversed-ph...
Sometimes it feels as if organic chemistry and chromatography are a mixture of art and science. Maybe its because of the necessary creativity needed to address the variety of challenges that we face a...
Cannabinoid isolation requires several steps from harvesting the biomass to extraction, winterization, decarboxylation (if desired), distillation, and finally chromatographic purification and isolatio...
Cannabidiolic acid, or CBDA, has purported analgesic properties relieving pain and inflammation[1]. CBDA is also the starting material for CBD which is produced through a procedure called decarboxylat...
As one of the major cannabinoids present in cannabis, Cannabigerol (CBG), is gaining interest as possible therapeutic. Though all other cannabinoids are created from CBGA (the acid form of CBG), it is...