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Per- and polyfluoroalkyl substances (PFAS) are a group of harmful organic compounds that are very persistent in structure. What this means is PFAS compounds accumulate in the environment over time as ...
If you’re a laboratory that’s processing drinking water samples using solid phase extraction, you’ve inevitably gotten to the step in your procedure where you’ve eluted your analytes from your SPE med...
In the first part of this 2-part blog series, I highlighted the improvements made by the EPA regarding the preparation and preservation of samples. In this post, I will focus more on the changes the E...
The U.S. EPA monitors a variety of compounds that pose public health risks when they are present in our air, soil or water and they have spent decades publishing methods to help us extract and quantif...
“Pesticides” is one of those terms that invokes a wide range of emotions in people. Some people smile when they think of the insecticides that keep their award-winning flower garden looking beautiful ...
Have you ever put your water sample onto your Biotage® Horizon 3100 extractor and all your prewet/conditioning steps worked great and then suddenly, the water inlet valve opens, and nothing happens! T...
As a chemist new to the peptide community, there are many choices that have to be made. Which coupling reagents to use? Heat or no heat to promote chemistry? And most importantly, which resin?
I have experimented a lot with disulfide rich peptides lately, finding conditions that work well for not only the linear synthesis, but also for on-resin cysteine oxidations. Although simple scaffolds...
More and more groups are exploring the utility of peptides with an ever widening variety of applications. And although peptides are getting cheaper to purchase outright, many groups are continuing to ...
In the past, when I have synthesized a new peptide, I always ran a “scout run” – a small scale injection, usually with an analytical HPLC column – to both get an idea of the crude purity and also to i...