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Hydrophilic Solution for Your Vapor Lock Dilemma
Water and Environmental Testing
Read our technical tips on how to deal with vapor lock in automated solid phase extraction.
How to choose the right resin functionality for solid phase peptide synthesis
Small Molecules and Synthetic Therapeutics
There are many available resins for solid phase peptide synthesis. Read more to learn about some of the choices and how they differ from ...
Synthesis of peptides containing three disulfide bonds: can it be fully automated?
Small Molecules and Synthetic Therapeutics
In this post, we'll put to use three orthogonal protection strategies to optimize a fully automated synthesis of linaclotide.
What is solid phase peptide synthesis?
Small Molecules and Synthetic Therapeutics
What is solid phase peptide synthesis and why was it developed? Read more to learn the differences between the two main synthesis ...
How to use a scouting column for your peptide purification
Small Molecules and Synthetic Therapeutics
Predicting peptide elution profile is critical for efficient peptide purifications. Learn how a scouting column, with matched stationary ...
Post synthesis workup: What steps are necessary and what aren't?
Small Molecules and Synthetic Therapeutics
Learn how to quickly and gently evaporate peptide cleavage cocktail, reducing your total peptide workflow time significantly.
How does methanol as a mobile phase solvent impact peptide purification by reversed-phase flash chromatography?
Small Molecules and Synthetic Therapeutics
Methanol is increasingly used for reversed phase purification in place of acetonitrile. Learn how methanol impacts your peptide ...
How long should I let my cleavage reaction stir at room temperature?
Small Molecules and Synthetic Therapeutics
Cleaving peptides from resin is often a very fast reaction, however side chain protecting groups may require more time. What reaction time ...
Optimizing a mobile phase gradient for peptide purification using flash column chromatography
Small Molecules and Synthetic Therapeutics
Reversed phase flash chromatography is growing in popularity as a strategy to purify crude peptide samples. Read more to how gradient ...
How to purify peptides using a step gradient in flash column chromatography
Small Molecules and Synthetic Therapeutics
Step gradients are often used in normal phase chromatography. Read more to learn how they can be used to also improve the purity of your ...
