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Chemical synthesis of peptides, and even proteins, offers the possibility to expand the functionality and stability imbued by nature. However, chemical synthesis of very long peptides and small protei...

Since its release in 1995, EPA method 525.2 has been one of the most widely used methods for quantifying semi-volatile compounds in drinking water. Chances are, if you work for or own a drinking water...

Per- and polyfluoroalkyl substances (PFAS) are a group of harmful organic compounds that are very persistent in structure. What this means is PFAS compounds accumulate in the environment over time as ...

If you’re a laboratory that’s processing drinking water samples using solid phase extraction, you’ve inevitably gotten to the step in your procedure where you’ve eluted your analytes from your SPE med...

In the first part of this 2-part blog series, I highlighted the improvements made by the EPA regarding the preparation and preservation of samples. In this post, I will focus more on the changes the E...

The U.S. EPA monitors a variety of compounds that pose public health risks when they are present in our air, soil or water and they have spent decades publishing methods to help us extract and quantif...

“Pesticides” is one of those terms that invokes a wide range of emotions in people. Some people smile when they think of the insecticides that keep their award-winning flower garden looking beautiful ...

Have you ever put your water sample onto your Biotage® Horizon 3100 extractor and all your prewet/conditioning steps worked great and then suddenly, the water inlet valve opens, and nothing happens! T...

As a chemist new to the peptide community, there are many choices that have to be made. Which coupling reagents to use? Heat or no heat to promote chemistry? And most importantly, which resin?

I have experimented a lot with disulfide rich peptides lately, finding conditions that work well for not only the linear synthesis, but also for on-resin cysteine oxidations. Although simple scaffolds...