When should I choose SPE instead of SLE?
When would I choose SLE? When would I choose SPE? We all have faced those questions. Let's have a look at the two sample preparation techniques.
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How to meet demands for detection limits with the right sample prep method
Highly sensitive techniques such as LC-MS/MS are enabling analytical laboratories to generate more data on more analytes in more samples, in less time, at a lower cost, and using smaller sample volume...
The revolution of microelution in solid phase extraction
Solid phase extraction (SPE) is frequently used for sample clean up, trace enrichment (pre-concentration of the sample), or a combination of both prior to analysis. But can solid phase extraction be a...
How to achieve faster sample prep, cleaner extracts, and instant sensitivity gains
A prime objective of bioanalytical sample preparation is to achieve high analyte recovery in low elution volumes, with rapid delivery of clean extracts that support robust high sensitivity analysis to...
Dilute & shoot ... yourself in the foot
Urine samples are composed of many interferents which can cause ion-suppression or ion-enhancement when analyzing by mass spec. Build up of these matrix components over multiple sample injections can ...
Putting it together: why should I tune my mass spectrometer?
What's the process behind tuning our analytes to the mass spectrometer’s optics? And why is that so important?
Troubleshooting Loss of Signal: Where did my peaks go?
Let’s take a look at one of the more irritating issues in LC/MS method development: signal loss. I’m not talking about signal attenuation, which can be much more convoluted to diagnose; but rather a c...
Why just measure Vitamin D when you can monitor Vitamins A, E and K as well?
A new method has been developed for the combined analysis of Vitamin A, Vitamin D, Vitamin E and Vitamin K from serum using LC-MS/MS. The method uses supported liquid extraction (SLE) with a novel sam...
Microelution plate processing: What pressure is best?
Microelution SPE is a great alternative to conventional SPE methods, enabling the use of lower wash and elution volumes, while maintaining sufficient load volumes, providing concentrated samples, perf...
No one wants to do sample prep if they don’t have to...
Many Labs today are faced with the challenge of having to do more with existing personnel and space. When looking at developing or modifying a LC/MS or GC/MS assay, one of the most important steps is ...