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With synthesizing new molecular entities (NMEs) our mission in life as chemists, we are innovators, creators even. In drug discovery research, these NMEs stand a good chance of becoming a cure for a m...
Chemistry, by its very nature, involves the use of chemicals that can be harmful, toxic and potentially damaging to the environment, which means that drug discovery currently has a large and expensive...
It (almost) doesn’t matter what the intended therapeutic outcome is, for virtually everyone who is working in the business of cannabis processing, CBD / THC remediation proceeds through well recognise...
In this blog, I will address something that is fundamental to years of classic process chemistry techniques. First disclaimer is that the pharma industry uses recrystallization for several purposes, n...
Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question I usually receive, relates to ho...
It’s engrained in our minds and psyche, from earliest school days and exposures to science that heating a reaction speeds it up. Later, we learn some more of the details, that by increasing the temper...
Another excellent question we received following seminars and presentations relates to the function and activity of metal scavengers. IUPAC nomenclature rules combined with various naming systems and ...
Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive ...
There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods...
Removing palladium has become more and more difficult for a number of reasons. Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducin...