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Whether for pharma, fine chemical, agrochemical, electronic or natural product research, in recent years, there has been increasing pressure to achieve and deliver higher purity products. Chemical pro...
I recently read an interesting paper from Graham Wynne and his many collaborators at the University of Oxford and CEMAS describing just how much residual palladium (Pd) is making its way through the s...
Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question we receive usually relates to ho...
After my seminars, I often receive questions from astute attendees on the topic of activated carbon, and how the more modern powerful approach of metal scavenging compares to the traditional applicati...
I am often asked why reversed-phase TLC data does not translate well to reversed-phase flash column chromatography. There are several reasons for this and in this post I will attempt to explain the ch...
Method transfer from reversed-phase TLC (thin layer chromatography) to reversed-phase flash column chromatography can be very challenging. Because of this, I often recommend using HPLC for reversed-ph...
Sometimes it feels as if organic chemistry and chromatography are a mixture of art and science. Maybe its because of the necessary creativity needed to address the variety of challenges that we face a...
COVID-19 caused accelerated research into developing vaccine options. Some of the created vaccines are based on mRNA which, if not protected, easily degrades in humans before its therapeutic benefits ...
Chemists are often taught how to use glass columns in schools, so they take fundamental background experience into industry which provides an intuitive advantage in process development applications. H...
For chemists performing bench-scale organic synthesis, flash column chromatography is often the primary purification technique. When synthesis needs scaling to multi-gram levels, so does the flash pur...