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I am often asked why reversed-phase TLC data does not translate well to reversed-phase flash column chromatography. There are several reasons for this and in this post I will attempt to explain the ch...
Method transfer from reversed-phase TLC (thin layer chromatography) to reversed-phase flash column chromatography can be very challenging. Because of this, I often recommend using HPLC for reversed-ph...
Sometimes it feels as if organic chemistry and chromatography are a mixture of art and science. Maybe its because of the necessary creativity needed to address the variety of challenges that we face a...
COVID-19 caused accelerated research into developing vaccine options. Some of the created vaccines are based on mRNA which, if not protected, easily degrades in humans before its therapeutic benefits ...
Chemists are often taught how to use glass columns in schools, so they take fundamental background experience into industry which provides an intuitive advantage in process development applications. H...
For chemists performing bench-scale organic synthesis, flash column chromatography is often the primary purification technique. When synthesis needs scaling to multi-gram levels, so does the flash pur...
Scale-up is a topic of paramount importance in the industry, drawing on inputs from safety, economic, regulatory and efficiency perspectives. Never before has so much attention focused on chemical syn...
Biotage is a leading global provider of equipment for drug discovery, life sciences and various chemical industries. Our products serve a range of clients in diverse applications, from purification of...
Large-scale chromatography is often the only solution to the purification of valuable drug compounds in the pharmaceutical industry. For many manufacturers, bespoke chromatography solutions seem the s...
There are fantastic global efforts to fight the spread of COVID-19 through therapies and vaccines and there is much research ongoing on optimizing the vital benefits that can be conferred by these inn...