Showing posts written by Biotage
Oral fluid represents a complex, heterogeneous biological fluid primarily produced by the parotid, submandibular, and sublingual salivary glands. Together, these glands make the majority of saliva, wh...
Drug screening using oral fluid has gained popularity over recent years due to its simple, non-invasive collection means. Screening drugs of abuse can be complicated due to the wide variation of funct...
Historically, silica-based solid phase extraction (SPE) cartridges have been used for drugs of abuse testing, the exact choice being dependent on drug functionality. GC/MS sensitivity requirements tra...
Achieving desired sensitivity of plasma catecholamines by LCMS/MS can be problematic. Low LOQs can require a highly sensitive MS instrument. Evaporation of the extracted sample can result in losses du...
Methylisothiazolinone (MI) is an antimicrobial preservative that is used in a variety of personal care products, such as sunscreens, lotions, cosmetics. MI is a cytotoxin and as a result there is conc...
Protein precipitation is a routinely used, high throughput sample preparation technique for removal of protein from biological fluid (plasma, serum or blood) samples prior to analysis by LC-MS/MS. His...
Hair analysis is growing in popularity due to the non-invasive nature of the sample collection. Although not used as routinely as other matrices such as blood or urine it does have advantages in that ...
Solid-phase extraction (SPE) is a powerful technique for rapid, selective sample preparation. Sample preparation prior to analysis is as important to the success of an assay as the analytical techniqu...
For research use only. NOT for use in diagnostic procedures.
This application note describes a method of extraction for metanephrine and normetanephrine from pooled plasma using EVOLUTE® EXPRESS WCX 96-well SPE plates. Figure 1. Structures metanephrine and norm...