The benefits of automating sample preparation
The main purpose of sample preparation is to extract the target analyte(s) from the sample matrix, allowing them to be measured by the chosen analytical technique, such as LC-MS/MS or GC-MS. This can ...
Literature
Showing posts tagged with "clinical-forensic-and-doping-testing"
Extraction of catecholamine acid metabolites from plasma
Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) are biomarkers for neuroblastoma and catecholamine secreting tumours. We present ...
A comparison of current methodologies for extraction of DoA from urine
Urine is a very useful matrix in forensic laboratories, because it is easy to collect and can help determine if a drug has been used recently. There are many viable sample preparation options for urin...
Practical considerations using Quantisal oral fluid collection devices
Oral fluid represents a complex, heterogeneous biological fluid primarily produced by the parotid, submandibular, and sublingual salivary glands. Together, these glands make the majority of saliva, wh...
Small molecules automated extraction from human breast milk using the Biotage® Extrahera™ and EVOLUTE® EXPRESS CX
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. At Biotage...
Methylmalonic acid: Evaluation of automated sample preparation and simplicity of method implementation
The screening for elevated levels of methylmalonic acid (MMA) in serum is commonly used as a clinical diagnostic indicator of Cobalamin (Vitamin B12) deficiency in humans. MMA is commonly analyzed usi...
Low cost entry for automation in laboratory settings
In the forensic world, many cases are decided based on the laboratory test results. Yet, while forensic testing is critically important for legal demands, many labs remain constrained by tight budgets...
Biotage® Extrahera™ LV-200 sample prep workstation
Introducing the Biotage® Extrahera™ LV-200. An automated sample prep workstation built to process sample volumes as low as 5 µL with the ease of manual sample prep and the digital integrity of a liqui...
ISOLUTE® PLD+ protein and phospholipid removal products
ISOLUTE® PLD+ protein and phospholipid removal plates and cartridges provide a very effective but extremely simple sample clean-up for LC-MS/MS analysis. Requiring next to no method development, ISOLU...
EVOLUTE® EXPRESS solid-phase extraction cartridges
EVOLUTE®® EXPRESS SPE cartridges combine powerful EVOLUTE® sorbent chemistry with enhanced ‘EXPRESS’ cartridge hardware in a range of SPE cartridge sizes. EVOLUTE® EXPRESS cartridges dramatically impr...