Showing posts tagged with "clinical-forensic-and-doping-testing"
Most drugs are excreted in urine as glucuronide conjugates. Hydrolysis using a beta-glucuronidase enzyme to convert the metabolites to their “free” form for analysis increases sensitivity. Red abalone...
ISOLUTE® SAX and PE-AX, the strong anion exchangers, are quaternary amines and therefore have a permanent positive charge under all pH conditions. Since this amine is tethered to the silica surface th...
Figure 1. Structural formulae of carbapenem antimicrobials. Introduction Meropenem and Doripenem (Figure 1) are carbapenem antimicrobials that inhibit bacterial cell-wall synthesis and have bactericid...
For research use only. NOT for use in diagnostic procedures. Figure 1. Structures of norepinephrine, epinephrine, dopamine, normetanephrine, metanephrine, and 3-methoxytyramine. Introduction This appl...
This application note describes a method of extraction for metanephrine and normetanephrine from pooled plasma using EVOLUTE® EXPRESS WCX 96-well SPE plates. Figure 1. Structures metanephrine and norm...
The use of ISOLUTE® HCX mixed-mode sorbents is widely accepted for providing high purity extracts of basic drugs from biological fluids. The dual retention mechanism, provided by non-polar and strong ...
Most drugs and metabolites are conjugated prior to excretion in the urine. Methods to detect drug analytes in urine usually include enzyme hydrolysis to convert glucuronide metabolites back to their f...
Drug screening using oral fluid has gained popularity over recent years due to its simple, non-invasive collection means. Screening drugs of abuse can be complicated due to the wide variation of funct...
Typical bioanalysis workflows for small molecules use organic solvents to precipitate proteins and extract analyte(s). Sometimes, extra clean-up, including liquid-liquid extraction (LLE) or solid phas...
Routine testing for drugs in urine is commonly performed by clinical, forensic, and pain management laboratories. The sample cleanliness required for analysis by LC-MS/MS can result in lengthy, labor-...