Showing posts tagged with "clinical-forensic-and-doping-testing"
Typical bioanalysis workflows for small molecules use organic solvents to precipitate proteins and extract analyte(s). Sometimes, extra clean-up, including liquid-liquid extraction (LLE) or solid phas...
Routine testing for drugs in urine is commonly performed by clinical, forensic, and pain management laboratories. The sample cleanliness required for analysis by LC-MS/MS can result in lengthy, labor-...
Buprenorphine and Norbuprenorphine are typically problematic for analysis due to analyte stability issues during sample preparation. A fast, reliable and robust sample preparation method that could be...
Oral fluid represents a complex, heterogeneous biological fluid primarily produced by the parotid, submandibular, and sublingual salivary glands. Together, these glands make the majority of saliva, wh...
Drug screening using oral fluid has gained popularity over recent years due to its simple, non-invasive collection means. Screening drugs of abuse can be complicated due to the wide variation of funct...
Historically, silica-based solid phase extraction (SPE) cartridges have been used for drugs of abuse testing, the exact choice being dependent on drug functionality. GC/MS sensitivity requirements tra...
Achieving desired sensitivity of plasma catecholamines by LCMS/MS can be problematic. Low LOQs can require a highly sensitive MS instrument. Evaporation of the extracted sample can result in losses du...
Methylisothiazolinone (MI) is an antimicrobial preservative that is used in a variety of personal care products, such as sunscreens, lotions, cosmetics. MI is a cytotoxin and as a result there is conc...
Protein precipitation is a routinely used, high throughput sample preparation technique for removal of protein from biological fluid (plasma, serum or blood) samples prior to analysis by LC-MS/MS. His...
Hair analysis is growing in popularity due to the non-invasive nature of the sample collection. Although not used as routinely as other matrices such as blood or urine it does have advantages in that ...