Literature

The main purpose of sample preparation is to extract the target analyte(s) from the sample matrix, allowing them to be measured by the chosen analytical technique, such as LC-MS/MS or GC-MS. This can ...

Introduction Discovering new chemical entities (NCEs) or new molecular entities (NMEs) is costly and time consuming. One needs only to look at the top 15 global pharmaceutical companies to see how exp...

Introduction As environmentally responsible chemists we all want to reduce the chemical waste volume we generate in our daily research activities. While the chemicals we use are necessary for what we ...

Chemical synthesis has been around for a long time - Hermann Kolbe first used the term ‘synthesis’ in the way in which modern chemists understand it in the 19th century1. Many of the important named r...

A flash column’s loading capacity varies depending on several factors but primarily the selectivity and resolution of the target compound from its closest eluting neighbors. While normal-phase flash c...

Introduction In the modern scientific environment, there is a constant desire to improve the speed and efficiency of processes in the development of new drugs, testing protocols and technologies. Comp...

Abstract Oral fluid is of increasing importance as a biological matrix in drugs of abuse and related analyte testing because of the ease of sample collection, and difficulty in adulteration of samples...

Introduction In the post genomic era of drug discovery, the need to prepare and analyze large numbers of recombinant proteins and antibodies has increased significantly, which in turn is driving the p...

What you'll learn The principles governing normal-phase and reversed-phase flash chromatography and how to select the most appropriate mode based on compound properties and purification objectives. Ho...

High performance: Remove >95% of salts with >80% yield of protein Retain protein functionality <10% CV in volume and concentration Ready for downstream assay Automated desalting/buffer exchange of fun...