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A prime objective of bioanalytical sample preparation is to achieve high analyte recovery in low elution volumes, with rapid delivery of clean extracts that support robust high sensitivity analysis to...
Urine samples are composed of many interferents which can cause ion-suppression or ion-enhancement when analyzing by mass spec. Build up of these matrix components over multiple sample injections can ...
What's the process behind tuning our analytes to the mass spectrometer’s optics? And why is that so important?
Let’s take a look at one of the more irritating issues in LC/MS method development: signal loss. I’m not talking about signal attenuation, which can be much more convoluted to diagnose; but rather a c...
A new method has been developed for the combined analysis of Vitamin A, Vitamin D, Vitamin E and Vitamin K from serum using LC-MS/MS. The method uses supported liquid extraction (SLE) with a novel sam...
Microelution SPE is a great alternative to conventional SPE methods, enabling the use of lower wash and elution volumes, while maintaining sufficient load volumes, providing concentrated samples, perf...
Many Labs today are faced with the challenge of having to do more with existing personnel and space. When looking at developing or modifying a LC/MS or GC/MS assay, one of the most important steps is ...
So, you’ve decided that you need to develop some new methods and one of the biggest challenges is the cost of developing and validating new methods. So, what to do to speed up the process?
Developing a new sample prep method should be systematic to ensure ruggedness and can be done quickly with the right tools. The days of using a vacuum manifold are gone, along with the variability and...
Correct pretreatment of samples prior to supported liquid extraction (SLE) produces better partitioning and cleaner extracts. Supported liquid extraction (SLE) is a simple clean-up technique similar t...