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Let’s take a look at one of the more irritating issues in LC/MS method development: signal loss. I’m not talking about signal attenuation, which can be much more convoluted to diagnose; but rather a c...
A new method has been developed for the combined analysis of Vitamin A, Vitamin D, Vitamin E and Vitamin K from serum using LC-MS/MS. The method uses supported liquid extraction (SLE) with a novel sam...
Microelution SPE is a great alternative to conventional SPE methods, enabling the use of lower wash and elution volumes, while maintaining sufficient load volumes, providing concentrated samples, perf...
Many Labs today are faced with the challenge of having to do more with existing personnel and space. When looking at developing or modifying a LC/MS or GC/MS assay, one of the most important steps is ...
So, you’ve decided that you need to develop some new methods and one of the biggest challenges is the cost of developing and validating new methods. So, what to do to speed up the process?
Developing a new sample prep method should be systematic to ensure ruggedness and can be done quickly with the right tools. The days of using a vacuum manifold are gone, along with the variability and...
Correct pretreatment of samples prior to supported liquid extraction (SLE) produces better partitioning and cleaner extracts. Supported liquid extraction (SLE) is a simple clean-up technique similar t...
Choosing the SLE correct elution solvent based on analyte properties produces the cleanest extracts with the highest recoveries.
This concept seems simple today, but traditional nitrogen evaporators haven’t been overhauled for many years. Even in our lab we were not able to store evaporation methods…until now!
It is easier to understand something when you know what the actual word means. A thermistor is a portmanteau (yes, sometimes I do pay attention to linguistics) of the words thermal and resistor. This ...