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What are good reversed-phase dry load options?
Small Molecules and Synthetic Therapeutics
This blog will help you understand dry loading, a sample loading technique that uses a blend of reaction mix/extract and sorbent.
What is Flash Chromatography and why should I do it?
Small Molecules and Synthetic Therapeutics
This is a basic overview of what flash chromatography is and why it is useful to chemists.
Flash column chromatography equilibration speed – how fast can you go?
Small Molecules and Synthetic Therapeutics
Flash column equilibration is important to ensure a proper separation occurs. This post discusses the impact of flow rate and equilibration ...
Prep HPLC vs. reversed-phase flash chromatography: How to choose?
Small Molecules and Synthetic Therapeutics
This post discusses the differences between RP flash and prep HPLC for compound purification.
How do I purify my high boiling solvent reaction mixture using silica flash chromatography?
Small Molecules and Synthetic Therapeutics
How do I purify my high boiling solvent reaction mixture using silica flash chromatography?
Why can’t I reproduce my TLC separation using flash column chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses options to separate and purify compounds by flash chromatography when TLC conditions have not successfully worked.
How does mobile phase organic solvent choice impact reversed-phase flash column chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses the role that the organic solvent plays in reversed-phase separation performance.
Why is Solvent Evaluation by TLC Important for Good Flash Chromatography Results?
Small Molecules and Synthetic Therapeutics
This post shows the benefits achievable when various solvents from different selectivity groups are used for method development using TLC.
When Should I Replace My Flash C18 Column?
Small Molecules and Synthetic Therapeutics
This post discusses the criterial for determining when to replace a used C18 column.
What is Orthogonal Flash Chromatography and Why Should I do it?
Small Molecules and Synthetic Therapeutics
This post shows the benefits obtained by purifying a reaction mixture using both normal- and reversed-phase flash chromatography.
