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I have previously posted on the topic of normal-phase optimization by evaluating different solvent blends or mixtures. I have also touched on reversed-phase method development as well suggesting chemi...
In previous posts I have discussed some options and techniques to improve detection of poorly absorbing or UV-transparent compounds – by wavelength focusing and by evaporative light-scattering (ELS).
Over the past several years, automated flash chromatography has evolved to include in-line mass detection. Typically, these single-quadrupole mass detectors are outfitted with either an atmospheric pr...
APCI (atmospheric pressure chemical ionization) and ESI (electrospray ionization) are the two most frequently utilized mass detection tools for automated flash chromatography.
Biotage, pioneers in flash chromatography, started packing columns with silica for flash purification 30 than years ago. Site director Chris Williams tells the story of packing columns - "part science...
This is an interesting question that does not have a straightforward answer. In fact, there are many materials that are potentially useful sorbents for dry loading crude mixtures. Some of the more pop...
For most synthesis and natural product chemists, flash chromatography is the primary tool for purification and isolation of compounds of interest. Purification methods include flash system defaulted l...
In our more environmentally aware climate, chemical and pharmaceutical companies now prioritize reducing organic solvent use in chemistry labs. Employees and shareholders alike are pushing their compa...
Various flash chromatography sample loading options are available including liquid and dry loading. Choosing the right technique is important because your sample loading choices (sample solvent and dr...
Biotage®, a pioneer in Flash Purification, launched the unique, removable cap SNAP flash chromatography columns in 2007. This beneficial column design feature continues with the newest Biotage flash c...