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In past posts I discussed which solvents work best for sample loading in reversed-phase flash chromatography. Recently, I was asked to provide some insight as which solvents are best in normal-phase f...

For chemists preferring or needing to dry load their crude sample mixtures to get an acceptable flash purification result, using the right ratio of sample to sorbent can be quite important. Too much s...

Flash chromatography is a standard part of an organic chemist’s workflow. It is utilized after most reaction steps in order to remove most of the generated by-products and excess reagents.

Varying the concentrations of mobile phase solvents during flash purification chromatography enhances the ability of the technique to effectively isolate the desired compound from reaction by-products...

When it comes time to purify your reaction mixture or natural product extract, you have a choice to make. Should you simply load your dissolved sample onto your flash column or take the extra step to ...

Our clientele at Biotage have interesting and diverse backgrounds from highly skilled synthetic chemists, to experts in natural product chemistry, to those who are just beginning they journey with che...

Choosing a good purification strategy is an important for successful crude compound purification. A major factor in your strategy is choosing between normal-phase or reversed-phase chromatography. How...

If you synthesize organic amine compounds, especially heterocyclic, secondary, or tertiary amines, you likely have encountered problems with their chromatography using silica columns. With the amine g...

Cannabinoids, naturally occurring compounds found mainly in cannabis and hemp, have seen significant research as potential new therapeutics during the past four to five years with the passing of the 2...

TLC is the tool most used for normal-phase flash chromatography method development. For many chemists, a solvent system of hexane (or heptane) + ethyl acetate is the first, and sometimes only, solvent...