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The absence of impurities in peptides, synthesized via SPPS, is vital for reliable assay results. However, especially in drug discovery screenings (number of peptides > 24), potentially low-purity cru...
Efficiency and reproducibility are critical for successful scale-up. Biotage flash purification solutions are designed for simple and seamless scale up from development to large-scale cGMP manufacturi...
Introduction The U.S. EPA has been regulating semi-volatile organic compounds in drinking water with Method 525 since 1988. There have been several method updates since then, but the most recent was i...
Abstract Life science researchers depend upon transient transfection to generate mammalian proteins with the full complement of post translational modifications. In this process, plasmid DNA passes th...
For research use only. NOT for use in diagnostic procedures.
Figure 1. Structure of Benzoylecgonine Introduction This application note describes the extraction of cocaine and major metabolites from whole blood, prior to GC/MS analysis. This protocol also allows...
Introduction Synthetic lipids and lipid nanoparticles (LNPs) have been used for mRNA-based drug administration for several years. The lipid mixtures typically contain four compounds, including cholest...
This application note describes the extraction of Vitamin D metabolites from human serum using ISOLUTE® SLE+ with LC-MS/MS analysis.
For research use only. NOT for use in diagnostic procedures. Figure 1. Structure of 6-monoacetylmorphine. Introduction This application note describes the fully-automated extraction of opiates from ac...
For research use only. NOT for use in diagnostic procedures. Figure 1. Example structures by class. Introduction This application note describes the extraction of mulitple drugs of abuse from human ur...