Showing posts tagged with "clinical-forensic-and-doping-testing"
Figure 1: Structural formula of mycophenolic acid. Introduction Mycophenolic acid (Figure 1) is an active metabolite produced by the hydrolysis of the immunosuppressive agent Mycophenolate Mofetil in ...
The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extra...
Hydroxychloroquine (HCQ) and chloroquine (CQ) are common antimalarial drugs with long half-lives. They are currently being tested as potential treatments for COVID-19. Due to their high publicity in t...
Clinical analysis encompasses a wide range of analytes, whether they are endogenous compounds such as amino acids, vitamins, and hormones or exogenous compounds ("xenobiotics"), such as prescribed and...
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. At Biotage...
This technical note describes the extraction of acidic drugs from biological fluids using ISOLUTE® HAX mixed-mode SPE products.
Solid-phase extraction is a powerful extraction technique which delivers high analyte recoveries and clean extracts. Micro elution SPE formats utilize very small amounts of extraction sorbents, suitab...
Introduction The objective of this study was to determine feasibility of transferring a validated liquid-liquid extraction method to a supported liquid extraction method using Biotage ISOLUTE® SLE+ 96...
This technical note describes the extraction of basic drugs from biological fluids using ISOLUTE® HCX mixed-mode SPE products. Sample preparation techniques such as protein precipitation, supported li...
Most drugs are excreted in urine as glucuronide conjugates. Hydrolysis using a beta-glucuronidase enzyme to convert the metabolites to their “free” form for analysis increases sensitivity. Red abalone...