Showing posts tagged with "clinical-forensic-and-doping-testing"
Introduction This application note describes a solid phase extraction (SPE) protocol for the extraction of teicoplanin from plasma prior to HPLC-DAD analysis. Teicoplanin (Figure 1) is a glycopeptide ...
Introduction This procedure is recommended for the extraction of a variety of diuretics from urine using non-polar polymeric SPE. The analyte suite includes thiazides, carbonic anhydrase inhibitors, l...
Introduction GS-441524 (Figure 1) is the main plasma metabolite of the antiviral drug remdesivir. Remdesivir is a nucleoside analogue antiviral drug developed by Gilead Sciences for the treatment of E...
Introduction Axitinib (Figure 1) is a type of molecularly targeted drug used in renal cell carcinoma. To avoid serious side effects and achieve maximal therapeutic efficacy, it is crucial to determine...
Cannabis is one of the most widely abused substances in the world. The naturally occurring cannabinoids found in plant species bind to receptors in the brain and cause sensations of relaxation and cal...
GC/MS is still a mainstay in forensic analysis for drugs of abuse testing in urine. Historically silica-based solid phase extraction (SPE) cartridges have been used for these target analytes, the exac...
Breastfeeding offers significant health benefits for both infants and mothers, promoting optimal nutrition, immune protection, and developmental outcomes. However, maternal use of illicit drugs or mis...
PFAS targets are of concern because of their high persistence, bioaccumulation and slow elimination with potential impacts on human and environmental health. Recently, human exposure has been linked w...
Two peptides, produced in the hypothalamus, oxytocin a 9-residue neuropeptide associated with parturition (childbirth) and lactation and vasopressin a peptide hormone associated with fluid retention a...
Early phase small animal drug trials have largely been the driver for miniaturization due to limited sample size. However, this trend is gaining popularity in forensic/clinical toxicology with respect...