Showing posts tagged with "clinical-forensic-and-doping-testing"
The screening for elevated levels of methylmalonic acid (MMA) in serum is commonly used as a clinical diagnostic indicator of Cobalamin (Vitamin B12) deficiency in humans. MMA is commonly analysed usi...
Propofol is used in clinical environments to induce states of anaesthesia or reduced sensitivity during surgical procedures. However, it also has the potential to be abused for short-term hallucinatio...
Exposure to per and polyfluoroalkyl substances (PFAS) has been linked with changes in metabolism, increased cholesterol, and high incidence of some forms of cancer. PFAS pose particular challenges in ...
Fentanyl and fentanyl-related analogues have been identified as the root cause of several notable mass-overdose events in recent years. The demand for testing of these drugs has rapidly increased due ...
Routine testing for drugs of abuse (DOA) in urine is commonly performed by many clinical, forensic, and pain management laboratories. The method of testing varies but can often provide unwanted load s...
The ISOLUTE® family of both endcapped and non-endcapped, non-polar, silica based sorbents are used to extract organic compounds from aqueous matrixes.
This application note describes the extraction of sirolimus, tacrolimus, everolimus, cyclosporin A from whole blood samples using supported liquid extraction prior to LC-MS/MS analysis.
Introduction Synthetic benzodiazepines are becoming more abused and are considered “legal highs”. Many forensic laboratories are finding more and more of these compounds in post-mortem and impairment ...
Figure 1: Structural formula of mycophenolic acid. Introduction Mycophenolic acid (Figure 1) is an active metabolite produced by the hydrolysis of the immunosuppressive agent Mycophenolate Mofetil in ...
The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extra...