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Organic chemistry syntheses often use polar, high boiling point solvents to facilitate high temperature reactions. However, these solvents also can complicate down-stream compound purification, either...
The issue of greener synthesis workflow is becoming more important as chemists, and the institutions that employ them, evaluate various ways to reduce organic solvent use in both synthetic and chromat...
This is a question I asked myself while I have been studying synthesis variables to see what, if any, impact each variable has on reaction product yield and purity. For this post, I evaluated the orde...
For my purification blog I often will synthesize compounds so I can show representative, real-world reaction product purification. In doing so, I decided I would also post on the impact of various syn...
As you know, reaction chemistry involves determining and selecting the right conditions for optimal product yield and purity. There are actually six variables, that I know of, needing consideration in...
This, of course, is always one of the first questions an organic, medicinal, or peptide chemist has when starting the research process for a flash chromatography system. Here at Biotage, we receive th...
While many of the standard amino acids can be purchased pre-loaded onto Wang type resins, there are still cases where coupling the first amino acid onto Wang resin manually is necessary. In my case, a...
For many synthetic chemists the primary purification goal is to isolate as much synthetic product as possible with a minimum of 80% purity. The go-to technique for product isolation is flash purificat...
Purifying your synthetic product efficiently in high yield with minimal impurities is every chemist’s goal. At discovery-scale, flash chromatography is the go-to purification technique as it is relati...
For chemists isolating their synthesized product in maximum yield and purity is a primary goal. Sometimes the crude reaction mixture stays in solution, sometimes it does not. In these cases, is it bet...