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In today’s post I’ll answer the above question by comparing the crude purity of peptides synthesized using amino acid stock solutions or freshly dissolved amino acids.
Synthesizing libraries of peptides - potentially hundreds in a single synthesizer setup - has seen a resurgence of late. These synthetic libraries, often prepared on very small synthesis scales, are r...
Breakthrough during reversed phase purification often occurs for only a couple of reasons: 1) the dissolution solvent is too strong and prevents the compound from fully interacting with the stationary...
Biotage® V-10 Touch rapidly dries samples dissolved in both aqueous and organic solvents. It easily evaporates HPLC fractions from purification, high boiling point solvents from synthesis and features...
Getting rid of solvent has long been a bottleneck in organic workflow. With the powerful Biotage® V-10 Touch evaporator, those days are gone. This system can evaporate DMSO and NMP with ease, meaning ...
Have you heard about Biotage® V-10 Touch? If you're struggling with rapidly drying samples dissolved in either aqueous or organic solvents, or evaporating HPLC fractions from purification and high boi...
Flash chromatography can be complex. Solvent choice, column size, stationary phase, loading technique, gradient method, flow rate, and detection parameters are all variables which factor into flash ch...
Flash chromatography is the most commonly used purification tool for organic and medicinal chemists whose reaction scales typically range from milligrams to grams. The column size to be used for the p...
Chemical reactions gone wrong, I’m sure we all have experienced this issue, I know I have. You add your reagents in the proper amounts with a suitable solvent and perform your reaction only to find yo...
Though this is a purification blog I do, from time to time, like to address synthetic chemistry experimentation findings in the desire to assist you with your reactions, as this is the front-end of yo...