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Automating stapled peptide synthesis: overcoming DMF poisoning
Small molecules and synthetic therapeutics
Fully automating synthesis and secondary chemistry is always desirable, unless it comes at a cost of yield or purity. Read more for ...
How does flow rate affect my peptide purification efficiency when using a small pore stationary phase
Small molecules and synthetic therapeutics
Particle size and pore size can both impact resolution, but especially when using reversed phase flash chromatography. Read more to see ...
Peptide Workflow in action at Red Glead Discovery
Small molecules and synthetic therapeutics
The articles contains an interview to Richard E. Johnsson, Ph.D., Head of Peptide Chemistry at Red Glead Discovery, Lund, Sweden, who ...
How many amino acid equivalents should I use for my microwave assisted synthesis?
Small molecules and synthetic therapeutics
The number of equivalents used in a synthesis can significantly impact the cost of a peptide synthesis. Read more to learn how few ...
Has my peptide undergone an aspartimide rearrangement?
Small molecules and synthetic therapeutics
Aspartimide rearrangements can negatively impact biological screening outcomes. Read more to learn methods to identify this side reaction ...
Preventing aspartimide rearrangements during fmoc-based solid phase peptide synthesis
Small molecules and synthetic therapeutics
Aspartimide rearrangements are one of the most ubiquitous side reactions encountered during solid phase synthesis. Read more to learn how ...
Which Stationary Phase Should I Chose For My Peptide Purification?
Small molecules and synthetic therapeutics
Choosing a stationary phase seems relatively straightforward, almost automatic even. See how selectivity differences could impact your ...
How to choose an ion pairing agent to improve your peptide purification
Small molecules and synthetic therapeutics
Sometimes closely eluting impurities are difficult to resolve by simply changing the gradient. Learn how ion pairing agents can help.
How to purify your peptide using mass directed flash chromatography
Small molecules and synthetic therapeutics
Mass directed purification simplifies purification efforts. Read more how it can be used to reduce your purification time with flash ...
Peptides containing cysteine: the role of scavengers in cleavage cocktail
Small molecules and synthetic therapeutics
In this blog, Beth highlights the role of of scavengers for peptides containing cysteine residues.
