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Extractable Petroleum Hydrocarbons (EPH) may be invisible, but their impact on the environment is tangible. Through advanced monitoring techniques and a robust regulatory framework, we strive to strik...
In the world of science, there are always new topics and compounds that are discovered, but not all of them get much publicity. One of these is acrylamide. Now you’re probably saying to yourself, “wha...
Often the question arises asking how can I extract both acids and bases with the same Supported Liquid Extraction (SLE) procedure. Is this possible? And how?
Unbiased peptide screening technologies have evolved, improved and recently gained acceptance by the community as strategies for identifying new lead compounds against old targets with in novel chemic...
Preparative HPLC and flash chromatography are two of the most utilized techniques for purifying molecules post synthesis. To monitor sample purity and elution times, detection techniques such as UV/UV...
Evaporative light-scattering detection (ELSD) is an effective tool for detecting compounds with minimal to no UV absorbance. ELS detectors convert the column effluent into an aerosol by adding heated ...
I like working with natural products, at least from a chromatography perspective. The sheer breadth of compounds extractable from a plant makes separations a challenge but overcoming that challenge wi...
ELSD, or evaporative light scattering detector, is an accessory item available for many commercially available flash chromatography systems. It is typically used to detect compounds that are UV transp...
Cl-trityl resin can be tricky to use not only from an amino acid loading perspective, but one must also consider the highly labile linkage to the solid support1. This lability is advantageous in insta...
Dry loading crude reaction mixtures can dramatically improve purification results. This is a topic I have blogged about several times and is important enough to discuss again.