Are all C18 Flash Columns the Same?
For many chemists, one flash chromatography column is the same as another and only price is considered. This is true for both silica and reversed-phase (C18). However, since there are differences betw...
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Homogenization and Extraction of PFAS from Solid Samples
When it comes to environmental sample testing, there’s no shortage of the types of toxic substances you can detect utilizing liquid chromatography with tandem mass spectrometry (LC-MS/MS). At the time...
What's the best way to scale-up flash chromatography?
Flash chromatography is an integral part of the organic synthesis workflow. For most chemists, they make a compound once and then move on to the next synthesis. Sometimes, the synthesis needs to be sc...
When should I use C18 rather than silica for flash chromatography?
Flash chromatography is nearly ubiquitous within organic and medicinal chemistry labs. Most chemists, when the need arises to purify a reaction mixture, will use a silica column (aka normal-phase) for...
What Really is a QuEChERS Cleanup?
Who knew there were so many different parts to a QuEChERS approach! The nice thing about QuEChERS is even though there are a few different steps to capture your target analytes, they are all Quick, Ea...
What is SGT-HEM and how do you test for it?
If you have ever worked in an environmental laboratory, you might have heard of EPA method 1664B. Method 1664B is an extraction method with analysis by gravimetry that measures oil and grease in waste...
What Exactly is QuEChERS and How is it an Extraction?
You might be saying to yourself, QuEChERS isn’t an extraction, it’s just QuEChERS! I know when I think extraction, I think of your traditional liquid-liquid or solid-phase extraction where you have a ...
What is an Isotope Dilution Standard?
When it comes to chromatographic analysis, it’s no surprise that the analytes of interest are the main focus. After all, those are the compounds one wishes to isolate and quantitate to report to their...
How to improve synthesis workflow by over 90%
Synthesis workflow is the journey taken by chemists when creating a molecule. This journey can be like taking the interstate with no traffic lights and higher speed limits but usually this trip is mor...
What should I use instead of DCM/MeOH flash chromatography for purification?
While polar compound purification is frequently performed using a silica column and a DCM/MeOH solvent system, there is a need to reduce its use in chromatography for a number of reasons. First, dichl...