What is SGT-HEM and how do you test for it?
If you have ever worked in an environmental laboratory, you might have heard of EPA method 1664B. Method 1664B is an extraction method with analysis by gravimetry that measures oil and grease in waste...
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What Exactly is QuEChERS and How is it an Extraction?
You might be saying to yourself, QuEChERS isn’t an extraction, it’s just QuEChERS! I know when I think extraction, I think of your traditional liquid-liquid or solid-phase extraction where you have a ...
What is an Isotope Dilution Standard?
When it comes to chromatographic analysis, it’s no surprise that the analytes of interest are the main focus. After all, those are the compounds one wishes to isolate and quantitate to report to their...
How to improve synthesis workflow by over 90%
Synthesis workflow is the journey taken by chemists when creating a molecule. This journey can be like taking the interstate with no traffic lights and higher speed limits but usually this trip is mor...
What should I use instead of DCM/MeOH flash chromatography for purification?
While polar compound purification is frequently performed using a silica column and a DCM/MeOH solvent system, there is a need to reduce its use in chromatography for a number of reasons. First, dichl...
Alumina sample cleanups and how can you implement in your workflow?
If you are working in an environmental lab and encounter tissue samples and highly contaminated petroleum soil samples that create a lot of noise and interference on your analytical instruments, then ...
How to demonstrate low background contamination for PFAS testing
Environmental laboratories are often required to demonstrate that their procedures do not introduce background contamination or interferences that would result in false positives or poor analytical pe...
Automating Sample Prep Boosts Analytical Lab Efficiency
Automated sample prep helps your lab to run more smoothly. Sample prep is often seen as a painful process that is time-consuming, laborious, complex, error-prone, and costly. But efficient sample prep...
How do I purify ionizable organic amine compounds using flash column chromatography?
For most organic reaction mixture purifications the process is fairly straightforward. Use hexane/ethyl acetate or, for polar compounds, DCM/MeOH. But what do you do if this doesn't work and your comp...
Purifying ionic compounds by flash column chromatography
One of the more challenging purifications is that of water-soluble, ionizable compounds. Typically, normal-phase with silica is not used because of the probable non-reversible interactions, especially...