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Silica flash columns are the most frequently used to purify reaction mixtures. Prepacked columns are available from a vast number of vendors as is the silica itself for those wishing to pack their own...
In synthetic organic chemistry, post-reaction work-up using solvent extraction is almost routine. Solvent-solvent extractions using immiscible solvents can remove impurities from the product prior to ...
Flash chromatography is a purification technique that, by its name, is designed to be fast. Faster than open column chromatography and faster than prep HPLC. Flash chromatography is faster due to the ...
Understanding the properties of different SPE sorbents can be confusing, refer to selecting sorbent chemistries for a refresher. But what happens at each step of these different SPE sorbents specifica...
An interesting question for synthesis chemists as the need for reversed-phase flash chromatography for both intermediates and final compounds increases. Historically, normal-phase flash chromatography...
When choosing the stationary phase for SPE understanding the functionality of your target molecule is of critical importance. In order to select the correct SPE chemistry we need to understand how fun...
For many chemists, one flash chromatography column is the same as another and only price is considered. This is true for both silica and reversed-phase (C18). However, since there are differences betw...
When it comes to environmental sample testing, there’s no shortage of the types of toxic substances you can detect utilizing liquid chromatography with tandem mass spectrometry (LC-MS/MS). At the time...
Flash chromatography is an integral part of the organic synthesis workflow. For most chemists, they make a compound once and then move on to the next synthesis. Sometimes, the synthesis needs to be sc...
Flash chromatography is nearly ubiquitous within organic and medicinal chemistry labs. Most chemists, when the need arises to purify a reaction mixture, will use a silica column (aka normal-phase) for...