Literature
Showing all posts
Extraction of THC isomers and metabolites from whole blood
Introduction Analysis of tetrahydrocannabinol (THC) and its isomers is crucial for understanding their pharmacological effects and legal implications of cannabis use, especially in clinical testing, f...
From peptide design to purified therapeutics in 48 hours
Dr Diego Núñez Villanueva is a Tenured Scientist at the Institute of Medicinal Chemistry of the Spanish National Research Council (IQM‑CSIC). Prior to this, he spent several years in the UK, working a...
Extraction of mycotoxins from grain using ISOLUTE® Myco
Introduction Mycotoxins are toxic metabolites produced by fungal molds on food crops. Regulation and legislation for testing of mycotoxin contamination have established which mycotoxins are prevalent ...
Evaluating sustainable ion-pairing agents in peptide chromatography
In peptide purification, mobile-phase acidity (available solution protons) strongly influences peptide charge-state distribution, retention, and separation selectivity. Trifluoroacetic acid (TFA) is w...
Benchmarking Biotage® Rening silica against commercial alternatives for normal-phase flash separations
Introduction Flash chromatography remains a cornerstone purification technique across pharmaceutical, academic, and industrial chemistry workflows due to its speed, scalability, and robustness.1 Perfo...
High-throughput, automated large-scale plasmid purification: Eliminating manual bottlenecks in the therapeutic pipeline
The rapid expansion of biologics discovery – from high-throughput antibody screening to the development of viral vectors for gene therapy – has created an unprecedented demand for high-quality, transf...
Automated clean-up of pesticides in spinach using ISOLUTE® cSPE for QuEChERS
QuEChERS is a sample preparation technique commonly used in food safety testing for pesticide residue analysis. This two-stage extraction and clean-up technique was developed to streamline sample proc...
Extraction of patulin from apple juice using ISOLUTE® Myco
Introduction Patulin is a mycotoxin produced by aspergillum and penicillium mold species commonly found on rotting apples. Although not a particularly potent toxin, patulin has been shown to be genoto...
Extraction of acrylamide from fried potato chips using ISOLUTE® SLE+
Introduction The method described in this application note achieves high recoveries of acrylamide in fried potato chips (crisps). The method is sensitive enough to measure levels as low as 10 ppb in a...