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Introduction Flash chromatography using elution gradients of dichloro- methane and methanol (DCM/MeOH) are the go-to purification technique for chemists trying to purify polar compound mixtures. Howev...
Summary Purification of synthetic peptides represents the largest bottleneck of the entire peptide workflow. Reversed-phase flash chromatography is gaining traction as a strategy to reduce this bottle...
Figure 1. Structure of Amphetamine and Ethylone Introduction This application note describes the extraction of a range of amphetamine-type compounds from whole blood, prior to GC/MS analysis. A protoc...
Figure 1. Molecular Structure of Voriconazole. Introduction Voriconazole (Figure 1) is a triazole-based antifungal drug that is widely used to treat fungal infections, including invasive aspergillosis...
Application Note Scope This application note will outline optimized methods for the extraction of polycyclic aromatic hydrocarbons from sea water using the Atlantic® HLB solid phase extraction disk pr...
Chemists often wonder about the influence of flow rate on their flash chromatography. Typically, the questions are: If I slow the flow rate will my separation improve? If I speed the flow rate will my...
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model Active Pharmaceutical Ingredient (API).
Introduction Structural and functional studies of membrane proteins remain a challenge due to difficulties in their handling. In the last decade, several lipoprotein based methods have been proposed f...
Synthesis of branched peptides is very challenging. Here we show the synthesis of a complex multi-branched peptide and how this process can be simplified using the innovative Biotage® Initiator+ Alstr...