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This application shows how the β-amyloid (1-42) peptide was successfully synthesized in 0.1 mmol scale on a Biotage® Initiator+ Alstra™ fully automated microwave peptide synthesizer.
Introduction The detection of per- and polyfluoroalkyl substances (PFAS) within our air, water, and soil has confirmed their place as persistent pollutants that pose significant health risks upon huma...
Introduction This application note describes a solid phase extraction (SPE) protocol for the extraction of teicoplanin from plasma prior to HPLC-DAD analysis. Teicoplanin (Figure 1) is a glycopeptide ...
Introduction This procedure is recommended for the extraction of a variety of diuretics from urine using non-polar polymeric SPE. The analyte suite includes thiazides, carbonic anhydrase inhibitors, l...
Introduction Labelled peptides are important tools to study molecular interactions1 and are increasingly utilized with the growing number of peptide-based therapeutics.2 Biological assays frequently r...
Acknowledgements: A very special thank you to Adirondack Environmental Services for working with us on finding a solution for reducing sample volumes for EPA Method 608.3.
Introduction Peptide nucleic acids (PNAs) are DNA mimics where the sugar phosphate backbone of DNA is replaced by a peptide backbone consisting of N-(2-aminoethyl)glycine units. The purine nucleo- bas...
Why do we need sample preparation? There are very few techniques that can reliably analyze raw samples. Components in the sample matrix frequently interfere with analysis and mask analytes, especially...
Introduction This application note will outline a procedure for the extraction and concentration of organic compounds in drinking water utilizing the Biotage® Horizon 5000, TurboVap® II with End-Point...
Introduction GS-441524 (Figure 1) is the main plasma metabolite of the antiviral drug remdesivir. Remdesivir is a nucleoside analogue antiviral drug developed by Gilead Sciences for the treatment of E...