A study of DryDisk® background contamination
Introduction The DryDisk® Separation Membrane was designed to replace conventional sodium sulphate in the drying of sample extracts. The DryDisk® is a hydrophobic membrane, consisting of a GORE-TEX® p...
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Showing posts written by Biotage
Method development guidelines: SPE using ISOLUTE® SCX 2 sorbents for the extraction of aqueous samples
The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extra...
Elevating protein purification efficiency: Transitioning from manual techniques to automated platforms
Small-scale protein purification is an efficient method for screening samples for protein expression, stability, and functionality as well scaling down process development workflows for drug candidate...
Choosing the appropriate solid-phase extraction sorbent for peptide library clean-up
Peptides have returned to the forefront of drug discovery efforts as unbiased screening technologies have improved and the rules defining passive cell permeability have been clarified. As a result, th...
Extraction of chloroquine and hydroxychloroquine from different biological matrices
Hydroxychloroquine (HCQ) and chloroquine (CQ) are common antimalarial drugs with long half-lives. They are currently being tested as potential treatments for COVID-19. Due to their high publicity in t...
Sample matrix clean-up using protein and phospholipid depletion technique for DoA analysis in whole blood
Clinical analysis encompasses a wide range of analytes, whether they are endogenous compounds such as amino acids, vitamins, and hormones or exogenous compounds ("xenobiotics"), such as prescribed and...
Automated extraction of 12 DoA from human breast milk using EVOLUTE® EXPRESS CX
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. At Biotage...
Sample preparation by mixed-mode SPE using ISOLUTE® HAX
This technical note describes the extraction of acidic drugs from biological fluids using ISOLUTE® HAX mixed-mode SPE products.
Improving analytical sensitivity and throughput using Biotage® Mikro SPE microelution plates
Solid-phase extraction is a powerful extraction technique which delivers high analyte recoveries and clean extracts. Micro elution SPE formats utilize very small amounts of extraction sorbents, suitab...
Biotage® Selekt Kompass license
Just like a compass guides you north, Biotage® Selekt Kompass keeps your chromatography on the right path. In regulated environments, precision matters, and Biotage® Selekt Kompass ensures every site ...