Showing posts written by Biotage
Introduction Peptide nucleic acids (PNAs) are DNA mimics where the sugar phosphate backbone of DNA is replaced by a peptide backbone consisting of N-(2-aminoethyl)glycine units. The purine nucleo- bas...
Why do we need sample preparation? There are very few techniques that can reliably analyze raw samples. Components in the sample matrix frequently interfere with analysis and mask analytes, especially...
Introduction This application note will outline a procedure for the extraction and concentration of organic compounds in drinking water utilizing the Biotage® Horizon 5000, TurboVap® II with End-Point...
Introduction GS-441524 (Figure 1) is the main plasma metabolite of the antiviral drug remdesivir. Remdesivir is a nucleoside analogue antiviral drug developed by Gilead Sciences for the treatment of E...
This application note describes the use of ISOLUTE® HM-N as a support material for pre-adsorption of a reaction mixture prior to flash chromatography. This approach is useful when loading reaction mix...
Whether for pharma, fine chemical, agrochemical, electronic or natural product research, in recent years, there has been increasing pressure to achieve and deliver higher purity products. Chemical pro...
This technical note provides a detailed procedure for the preperation of PFAS compounds according to ISO 21675.
Introduction Axitinib (Figure 1) is a type of molecularly targeted drug used in renal cell carcinoma. To avoid serious side effects and achieve maximal therapeutic efficacy, it is crucial to determine...
The ALC-0315 lipid (Figure 1) gained worldwide recognition as a component of the SARS-CoV-2 vaccine [BNT162b2, developed by BioNTech and Pfizer]. Today, it is one of several lipid-based components use...
Introduction Flash chromatography has evolved from manual techniques using silica pads and glass columns to automated systems with prepacked silica columns. This shift has significantly improved purif...