Large scale microwave heated SPPS of the ACP (65–74) fragment using Biotage® Initiator+ Alstra™
This application note demonstrates a variable scale synthesis on the Biotage® Initiator+ Alstra™ using the ACP (65–74) fragment as a model peptide.
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Determination of microcystins in water using automated SPE and concentration techniques
Application note scope This application note will outline appropriate methods for the extraction of microcystins in water using Biotage automated or manual SPE solutions and the DryVap™* Concentrator ...
Fully automated optimized synthesis, on-resin oxidation, and purification of isotopically labelled oxytocin
This application note describes optimization for a fully automated synthesis and on-resin cyclization of oxytocin enabled by Branches™ , a unique software feature of the Biotage® Initiator+ Alstra™ pe...
Sample preparation techniques for synthetic benzodiazepines
Introduction Synthetic benzodiazepines are becoming more abused and are considered “legal highs”. Many forensic laboratories are finding more and more of these compounds in post-mortem and impairment ...
Recommended procedure for the preparation of PFAS compounds according to US EPA 537.1
This technical note provides a detailed procedure for the preparation of PFAS compounds according to EPA method 537.1.
Sample preparation method for determination of mycophenolic acid in plasma using ISOLUTE® SLE+
Figure 1: Structural formula of mycophenolic acid. Introduction Mycophenolic acid (Figure 1) is an active metabolite produced by the hydrolysis of the immunosuppressive agent Mycophenolate Mofetil in ...
The determination of dispersed oil in water using automated SPE in compliance with OSPAR and ISO 9377-2 methods in Norway
Scope This application note will outline the appropriate methods for the extraction of dispersed oil in water in compliance with OSPAR and ISO9377-2 methods, using Biotage automated or manual SPE solu...
A study of DryDisk® background contamination
Introduction The DryDisk® Separation Membrane was designed to replace conventional sodium sulphate in the drying of sample extracts. The DryDisk® is a hydrophobic membrane, consisting of a GORE-TEX® p...
Method development guidelines: SPE using ISOLUTE® SCX 2 sorbents for the extraction of aqueous samples
The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extra...
Elevating protein purification efficiency: Transitioning from manual techniques to automated platforms
Small-scale protein purification is an efficient method for screening samples for protein expression, stability, and functionality as well scaling down process development workflows for drug candidate...