Showing posts written by Biotage
Peptides have returned to the forefront of drug discovery efforts as unbiased screening technologies have improved and the rules defining passive cell permeability have been clarified. As a result, th...
The evolution of hemp processing to isolate non psychoactive cannabinoids has expanded from almost exclusively cannabidiol (CBD) to other, minor cannabinoids – CBG, CBC, CBL, CBCT, CBDV – to name a fe...
This technical note describes the extraction of basic drugs from biological fluids using ISOLUTE® HCX mixed-mode SPE products. Sample preparation techniques such as protein precipitation, supported li...
When working in a commercial testing laboratory, time is everything, and some days it feels like a never-ending journey just to get set up to start your extractions. A typical day would start by makin...
Peptide drug discovery efforts are increasing as unbiased screening technologies have improved and strategies to evaluate passive cell permeability have been defined. As a result, the demand for synth...
Most drugs are excreted in urine as glucuronide conjugates. Hydrolysis using a beta-glucuronidase enzyme to convert the metabolites to their “free” form for analysis increases sensitivity. Red abalone...
Introduction The process of drug discovery over the last 50 years has seen momentous change1. In the 1950’s, lead molecules were found largely by serendipity through in vivo screening of the chemical ...
ALC-0315 attracted global attention as a lipid component of the SARS-CoV-2 vaccine [BNT162b2, from BioNTech and Pfizer]. Lipids stabilize and increase the useful bioavailability of the mRNA therapies....
ISOLUTE® SAX and PE-AX, the strong anion exchangers, are quaternary amines and therefore have a permanent positive charge under all pH conditions. Since this amine is tethered to the silica surface th...
Biotage C18 PhyTip® column benefits Bind a Wide Range of Sizes of Protein/Peptide Sizes Exhibit a High Absolute Binding Capacity Process Results in Low Loss of Peptide Sample Compatible with many comm...