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The ability to extract a broad range of different drugs from a biological matrix allows for the expedited analysis of a patient sample using LCMS- MS. Typically small molecules are extracted from matr...
US EPA method 625 is used to determine acidic, basic, and neutral semi-volatile organic compounds (SVOC) in municipal and industrial wastewater. Revision A of this method is applied to a total possibl...
In medicinal chemistry each intermediate and final product needs purification. Historically, the primary tool for reaction purification has been normal-phase flash chromatography sometimes followed by...
Evaporative crosstalk is well-to-well cross contamination during extract evaporation after SLE or SPE extraction in a 96 well plate. It is often observed with volatile analytes like methamphetamine an...
The opioid crisis in the United States has necessitated monitoring of these drugs in biological fluids by many state health laboratories. Urine is a common matrix for analysis, and labs require a simp...
Traditionally, peptide purification has relied on preparative high performance liquid chromatography (prep-HPLC), known for its excellent resolution and impurity removal. However, this method is often...
Estrogen, androgen, and glucocorticoid metabolism can be used to assess overall hormonal balance during hormone therapy. Urine is the recommended testing matrix for quantification of primary estrogen ...
Part of the B complex group of water soluble vitamins, vitamin B7 is involved in various metabolic processes within the body. It is a small polar carboxylic acid which can present challenges in bioana...
Urine drug testing to support pain management is a mainstay of the clinical toxicology laboratory. Reduced reimbursement has continued to put increasing pressure on laboratories. Many toxicology labs ...
Solid phase peptide synthesis (SPPS) is used in the production of more than 80% of commercially manufactured peptides, and to an even greater extent at smaller scales. With the passing of the REACH Ac...