Synthesis of long peptoid molecules for nanomaterial assembly on Biotage® Initiator+ Alstra peptide synthesizer
Introduction
Literature
Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
Automated synthesis of a complex multibranched peptide using the Biotage® Initiator+ Alstra™ ‘Branches’ software feature
Synthesis of branched peptides is very challenging. Here we show the synthesis of a complex multi-branched peptide and how this process can be simplified using the innovative Biotage® Initiator+ Alstr...
Reducing the bottleneck in target synthesis
Executive summary Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales ...
Faster workflow with Biotage® V-10 evaporator at Sanford Burnham Prebys
Figure 1: Pictured, left to right, Paul Hershberger, Patrick Maloney, Mahesh Peddibhotla, and Hampton Sessions. Not pictured, Daniela Divlianska
Parallel peptide synthesis at elevated temperatures with Syro
This application demonstrates the reproducible multiple peptide synthesis on a Syro parallel peptide synthesizer equipped with Syro heating blocks. Effective heat transfer combined with efficient vort...
Unlocking the advantages of combining evaporative light-scattering and uv detection in flash chromatography
Introduction Evaporative Light-Scattering Detection, or ELSD, is utilized in flash chromatography to identify non-UV absorbing compounds. The ELSD is typically an optional accessory integrated with th...
Choosing the solid-phase extraction media for synthetic peptide clean-up
Summary Solid phase extraction (SPE) is a commonly used method to clean up various types of samples before analyzing them using LCMS. It is also an effective way to improve the purity of crude synthet...
Evaluation of on-resin head-to-tail cyclization protocols of peptides using automated peptide synthesizers
Peptide drug discovery programs have advanced to the clinic as the rules for small molecule-like transport and bioavailability have become more thoroughly understood. Macrocyclic peptides, in particul...
Stapled peptides: Optimizing ring-closing metathesis for automation
Peptides are well suited for use as tool compounds to interrogate biological systems and processes due to their chameleonic ability to mimic a potential protein partner within the biological system of...