Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
Summary Purification of synthetic peptides represents the largest bottleneck of the entire peptide workflow. Reversed-phase flash chromatography is gaining traction as a strategy to reduce this bottle...
Chemists often wonder about the influence of flow rate on their flash chromatography. Typically, the questions are: If I slow the flow rate will my separation improve? If I speed the flow rate will my...
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model Active Pharmaceutical Ingredient (API).
Introduction Structural and functional studies of membrane proteins remain a challenge due to difficulties in their handling. In the last decade, several lipoprotein based methods have been proposed f...
Synthesis of branched peptides is very challenging. Here we show the synthesis of a complex multi-branched peptide and how this process can be simplified using the innovative Biotage® Initiator+ Alstr...
Executive summary Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales ...
Figure 1: Pictured, left to right, Paul Hershberger, Patrick Maloney, Mahesh Peddibhotla, and Hampton Sessions. Not pictured, Daniela Divlianska
This application demonstrates the reproducible multiple peptide synthesis on a Syro parallel peptide synthesizer equipped with Syro heating blocks. Effective heat transfer combined with efficient vort...
Introduction Evaporative Light-Scattering Detection, or ELSD, is utilized in flash chromatography to identify non-UV absorbing compounds. The ELSD is typically an optional accessory integrated with th...