Literature

Peptide nucleic acids (PNAs) continue to gain traction in diagnostic and potentially therapeutic applications where oligonucleotides are the current modality of interest. Despite containing an unnatur...

To synthesize cyclic peptides, automated peptide synthesizers using solid phase supports have been the method of choice utilizing cyclization techniques such as lactam and disulfide bridges to impart ...

Synthetic chemistry is hard enough; purifying the reaction product can be even more challenging. If your reaction mixture shows you made your target but also many byproducts, what do you do? You can r...

Summary The automated gradient optimization feature in Biotage® Selekt flash purification systems accelerates purification, reduces solvent usage, and maintains loading capacity.

A branched peptidoglycan mimic and a tetra-branched antimicrobial peptide analogue were synthesized on a lysine scaffold using Biotage® Initiator+ Alstra™ microwave peptide synthesizer. These peptide ...

Introduction Flash chromatography using elution gradients of dichloro- methane and methanol (DCM/MeOH) are the go-to purification technique for chemists trying to purify polar compound mixtures. Howev...

Summary Purification of synthetic peptides represents the largest bottleneck of the entire peptide workflow. Reversed-phase flash chromatography is gaining traction as a strategy to reduce this bottle...

Chemists often wonder about the influence of flow rate on their flash chromatography. Typically, the questions are: If I slow the flow rate will my separation improve? If I speed the flow rate will my...

This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model Active Pharmaceutical Ingredient (API).

Introduction Structural and functional studies of membrane proteins remain a challenge due to difficulties in their handling. In the last decade, several lipoprotein based methods have been proposed f...