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If you use automated flash chromatography you may have a system than can have four solvents attached to it. In fact, most flash chromatography systems are designed to have as many as four solvents ava...

Head-to-tail cyclization of peptides is being used in drug development as yet another way to probe how constraining peptide sequence structure in solution can improve pharmacokinetics and target speci...

We all know the adage “Time is Money”. It is particularly true in pharma where the timeline to get a pharmaceutical product to market can take 10+ years and cost billions of dollars. With this as the ...

The big question…what affects cyclization efficiency? This is what I have been trying to answer over the course of the last few experiments, especially when it comes to head-to-tail macrocycles. I hav...

With the increasing use of reversed phase flash chromatography in medicinal chemistry and organic synthesis labs comes the desire to speed up and make these purifications more time and solvent efficie...

Have you ever had a purified reaction product, which should be white, retain color after purification? If so, what did you do to remove it?

With the increased use of reversed phase flash chromatography for reaction mixture purification comes a lot of questions since many chemists are not as familiar with this technique as they are with no...

Flash chromatography is a great tool to purify reaction mixtures and natural product extracts. Modern flash chromatography instrumentation incorporates UV detectors to see eluting compounds and trigge...

The dynamics of solid phase peptide synthesis at the resin surface makes it particularly difficult to create head to tail macrocycles. Dimerization, steric hinderance, and C-terminal access all reduce...

Silica dissolution in methanol is a concern many chemists have. Over my career I have heard that complaint probably hundreds of times which invariably leads to the question - how much methanol can I u...