|Chemical description||Octyl (C8, non-endcapped) and quaternary amine (-NR3+)|
|Sorbent type||Mixed-mode (non-polar and strong anion exchange)|
|Average particle size||50 µm|
|Pore diameter||60 Å|
This method was developed for the extraction of the tetrahydrocannabinol carboxylic acid metabolite (THC-COOH) from urine using a mixed non-polar and anion exchange retention mechanism. Typical recoveries of the analyte are > 75%.
THC, THC-COOH, BIOTAGE, ISOLUTE, SPE, DOA, drugs of abuse
Tags: Application Notes, Column, Forensic, GC-MS, THC-COOH, Urine
Tags: Application Notes
In this catalog product information is displayed with easy-to-follow application details and supporting documentation.
Ordering information is found following each product listing.
The first decision that needs to be made is what the final analysis will be for the analyte. This will have an impact on the sample and cartridge size, as well as the final elution solvent. Gas chromatography offers higher sensitivity than HPLC, while HPLC is better suited for ionisable species and very high molecular weights. If LC-MS is available, minimal sample clean-up may be required.
Tags: Manuals & User Guides
This poster uses gel electrophoresis data to visually illustrate the amount of residual protein in extracts prepared using protein precipitation, supported liquid extraction and various silica and polymer based SPE approaches.
Tags: Biological fluids, English, HPLC, LC-MS/MS, Plasma, Posters
Sample preparation techniques such as protein precipitation, supported liquid extraction or non-polar SPE may not be selective enough to give extracts of sufficient purity for low level analysis. In these cases, the selective mixed-mode approach to the extraction of basic and acidic drugs is a suitable alternative, giving very high purity extracts with minimal levels of co-extracted material.
Tags: Product Notes
ISOLUTE HAX mixed-mode SPE sorbent is based on a combination of strong anion exchange and non-polar chemistries. Acidic drugs are retained by two primary retention mechanisms. This allows a rigorous interference elution regime to be used to elute interferences retained by either non-polar or anion exchange interactions alone. Only analytes with both non-polar and acidic characteristics are extracted usign the ISOLUTE HAX sorbent, providing an extremely pure final extract.
Tags: Product Notes
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What is the maximum capacity of an SPE column?
The capacity of a sorbent is defined as the total mass of strongly retained analyte that can be retained by a given mass of the sorbent under optimum conditions.
For most sorbents, this can range from 1-5% by weight. 100 mg of sorbent might retain 1-5 mg of analyte.
Ion exchange sorbents typically have a capacity of 0.3-1 meq/g.Browse more questions and answers >
|Part No.||Description||Product type||Pack Size||Price|
|903-0010-A||ISOLUTE HAX 100 mg/1 mL||Consumables||100||Log in for price|
|903-0020-B||ISOLUTE HAX 200 mg/3 mL||Consumables||50||Log in for price|
|903-0020-C||ISOLUTE HAX 200 mg/6 mL||Consumables||30||Log in for price|
|903-0020-H||ISOLUTE HAX 200 mg/10 mL (3 mL XL)||Consumables||50||Log in for price|
|903-0025-P01||ISOLUTE-96 HAX 25 mg plate||Consumables||1||Log in for price|