Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
Peptide drug discovery efforts are increasing as unbiased screening technologies have improved and strategies to evaluate passive cell permeability have been defined. As a result, the demand for synth...
ALC-0315 attracted global attention as a lipid component of the SARS-CoV-2 vaccine [BNT162b2, from BioNTech and Pfizer]. Lipids stabilize and increase the useful bioavailability of the mRNA therapies....
Summary and background Purifying reaction mixtures often requires large volumes of solvent and multiple fraction collection vessels, especially when working at larger scales. Greener, more sustainable...
Peptide nucleic acids (PNAs) continue to gain traction in diagnostic and potentially therapeutic applications where oligonucleotides are the current modality of interest. Despite containing an unnatur...
To synthesize cyclic peptides, automated peptide synthesizers using solid phase supports have been the method of choice utilizing cyclization techniques such as lactam and disulfide bridges to impart ...
Synthetic chemistry is hard enough; purifying the reaction product can be even more challenging. If your reaction mixture shows you made your target but also many byproducts, what do you do? You can r...
Summary The automated gradient optimization feature in Biotage® Selekt flash purification systems accelerates purification, reduces solvent usage, and maintains loading capacity.
A branched peptidoglycan mimic and a tetra-branched antimicrobial peptide analogue were synthesized on a lysine scaffold using Biotage® Initiator+ Alstra™ microwave peptide synthesizer. These peptide ...
Introduction Flash chromatography using elution gradients of dichloro- methane and methanol (DCM/MeOH) are the go-to purification technique for chemists trying to purify polar compound mixtures. Howev...