Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
For most organic and natural product chemists flash chromatography is a necessary part of their research. As such, many chemists need quick isolation of at least one desired component from a crude mix...
Disulphide rich peptides exhibit exquisite stability due to the covalent stabilization of their secondary structure. After a particular sequence has been identified and mapped, these peptides are typi...
In medicinal chemistry each intermediate and final product needs purification. Historically, the primary tool for reaction purification has been normal-phase flash chromatography sometimes followed by...
Traditionally, peptide purification has relied on preparative high performance liquid chromatography (prep-HPLC), known for its excellent resolution and impurity removal. However, this method is often...
Solid phase peptide synthesis (SPPS) is used in the production of more than 80% of commercially manufactured peptides, and to an even greater extent at smaller scales. With the passing of the REACH Ac...
Flash chromatography is the primary tool used by medicinal chemists for reaction mixture purification. Over the past 10 or so years, the use of reversed-phase flash chromatography for reaction mixture...
There are many companies manufacturing flash columns and media. By and large, a column from any of the manufacturers will likely perform a purification with the right method – but how well? The silica...
Antimicrobial peptides (AMPs) are evolutionarily conserved peptide sequences often found in plants, animals, and humans. They play a significant role in the host’s innate immune response by acting as ...
Summary This application note highlights how simple Gradient Optimization and single vessel product collection – enabled by a collection bed bypass function - minimized solvent use and reduced the num...
Introduction The interest in naturally occurring and designed bioactive cyclic peptides is ever increasing.1–4 Cyclic peptides often have an increased stability against proteolysis compared with linea...