Literature

The Pentelute Lab at MIT uses Biotage® Selekt flash chromatography to rapidly purify synthetic peptides, accelerate hit discovery and move research forward with less time spent on purification.

Dr Diego Núñez Villanueva is a Tenured Scientist at the Institute of Medicinal Chemistry of the Spanish National Research Council (IQM‑CSIC). Prior to this, he spent several years in the UK, working a...

In peptide purification, mobile-phase acidity (available solution protons) strongly influences peptide charge-state distribution, retention, and separation selectivity. Trifluoroacetic acid (TFA) is w...

Introduction Flash chromatography remains a cornerstone purification technique across pharmaceutical, academic, and industrial chemistry workflows due to its speed, scalability, and robustness.1 Perfo...

Introduction Large numbers of related peptides are often required for many types of research, for example in proteomic studies of post-translational modifications. While this sometimes can be achieved...

Introduction The UV absorption spectrum of some solvents overlaps with the product they dissolve, meaning that fraction collection processes cannot distinguish between solvent and product. Luckily, th...

This application shows how the β-amyloid (1-42) peptide was successfully synthesized in 0.1 mmol scale on a Biotage® Initiator+ Alstra™ fully automated microwave peptide synthesizer.

Introduction Labelled peptides are important tools to study molecular interactions1 and are increasingly utilized with the growing number of peptide-based therapeutics.2 Biological assays frequently r...

Introduction Peptide nucleic acids (PNAs) are DNA mimics where the sugar phosphate backbone of DNA is replaced by a peptide backbone consisting of N-(2-aminoethyl)glycine units. The purine nucleo- bas...