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    Polar SPE

    All the phases on this page extract analytes from non-polar (typically solvent) matrices using polar retention mechanisms.

    The strength and selectivity of retention varies with sorbent type and matrix (solvent) characteristics.

    cond-equil-load-wash-elute

    Polar phase with enhanced capacity for acidic analytes.

    ISOLUTE® AL-A

    Polar, neutral phase, extracts electron rich aromatic compounds or those containing N, O, P & S heteroatoms.

    ISOLUTE® AL-N

    Polar phase with enhanced capacity for basic analytes.

    ISOLUTE® AL-B

    Retains analytes via dipole-dipole interactions.  Good for analytes that are difficult to elute from other polar sorbents.

    ISOLUTE® CN

    Retains analytes via hydrogen bonding and dipole-dipole interactions. Weaker retention than SI.

    ISOLUTE® DIOL

    An alternative to SI medias. Minimal retention of basic compounds. Activated for separation of chlorinated pesticides.

    ISOLUTE® FL

    Highest capacity for polar interactions. retains analytes via hydrogen bonding, dipole-dipole and weak cation exchange interactions (if trace water is present).

    ISOLUTE® SI

    Retains analytes via hydrogen bonding and dipole-dipole interactions.

    ISOLUTE® NH2

    Retains analytes via hydrogen bonding and dipole-dipole interactions.

    ISOLUTE® PSA

    About Biotage

    Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Our expertise and top-tier separation solutions play a key role in streamlining our customers’ workflows and improving their outcomes. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).

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    ISOLUTE Polar Solid Phase Extraction (SPE)