BIOMARK002.426 - Cross Talk SM

    Preventing Cross Talk

    Highlighted Applications

    Avoiding false positive results from sample to sample contamination is critical, and the use of 96-well plates may increase the risk due to close proximity of high concentration samples.

    Evaporating ultra high concentration samples

    Urine specimens analyzed by LC-MS/MS with analyte concentrations in excess of 100,000 ng/mL have been observed in some laboratories. Controlling crosstalk for these samples with such high concentrations presents a special challenge and is particularly difficult for volatile analytes like sympathomimetic amines.

    This poster examines strategies to prevent cross talk for ultra high concentration samples.


    Avoiding Cross Talk In 96-well Based Sample Preparation

    This guide aims to describe simple practical strategies, hints and tips designed to mitigate or avoid cross-well contamination or ‘cross talk’ in high throughput 96-well based sample preparation techniques.



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