Forensic and toxicology sample preparation

Extraction of synthetic cannabinoids in human whole blood using SLE

This ISOLUTE® SLE+ extraction method with analysis by LC-MS/MS extracted the novel synthetic cannabinoids from whole blood with recoveries of greater than 60%.

Extraction of PEth biomarkers in human whole blood using ISOLUTE® SLE+

This application note describes the extraction of a panel of three phosphatidylethanol (PEth) alcohol biomarkers from human whole blood using ISOLUTE® SLE+.

Extraction of barbiturates from whole blood using ISOLUTE® SLE+

This application note describes the extraction of barbiturate compounds from whole blood, prior to GC/MS analysis.

Extraction of benzodiazepines from whole blood using ISOLUTE® SLE+

This application note describes the extraction of benzodiazepine compounds from whole blood, prior to GC/MS analysis.

Extraction of opiates from whole blood using ISOLUTE® SLE+

This application note describes the extraction of opiate compounds from whole blood, prior to GC/MS analysis.

Extraction of cocaine and metabolites from whole blood using ISOLUTE® SLE+

This application note describes the extraction of cocaine and major metabolites from whole blood, prior to GC/MS analysis.

Automated extraction of THC and its metabolites from human whole blood with ISOLUTE® HAX using Biotage® Extrahera™ HV-5000

This application note describes the extraction of THC and its metabolites from human whole blood using ISOLUTE® HAX and Biotage® Extrahera™ HV-5000

Extraction of DoA panel from human urine using Biotage® Mikro ABN

This application note describes the extraction of 49 drugs of abuse from human urine using Biotage® Mikro ABN microelution plates.

Current methodologies for drugs of abuse urine testing, part 1

We present sample preparation considerations for a panel of 56* drug analytes by three different sample preparation methods.

Current methodologies for drugs of abuse urine testing, part 2

The need to expand a wider degree of drug monitoring within a single method has been increasingly sought after.

Automated extraction of amphetamines from human urine using ISOLUTE® HCX with Biotage® Extrahera™ HV-5000

This application note describes the extraction of amphetamines from human urine using ISOLUTE® HCX SPE cartridges and Biotage® Extrahera™ HV-5000

Extraction of benzodiazepines from human urine using ISOLUTE® SLE+

This application note describes the extraction of benzodiazepines from human urine using ISOLUTE® SLE+ prior to derivatization and GC-MS analysis.

Practical considerations using Quantisal® oral fluid collection devices and SPE method development by polymeric mixed-mode cation exchange

In this white paper we examine recovery and matrix effects for 85 common DOAs, when collected using the Quantisal device.

Automated extraction of opiates from hydrolyzed and non-hydrolyzed urine using ISOLUTE® SLE+

This application note describes the fully-automated extraction of opiates from acid-hydrolyzed urine and non-hydrolyzed urine prior to GC/MS analysis.

Extraction of synthetic cannabinoids from oral fluid using ISOLUTE® SLE+

This application note describes the extraction of a range of SPICE drugs and metabolites from neat oral fluid and oral fluid.

Streamlined sample preparation of DoA panel in human hair using ISOLUTE® SLE+

This application note describes a streamlined procedure for sample pre-treatment and extraction of a panel of 49 drugs of abuse from human hair.

Extraction of THC and its metabolites from human hair using ISOLUTE® SLE+ prior to UPLC-MS/MS analysis

This application note describes a procedure for sample pre-treatment and extraction of THC and metabolites from human hair.

Synthetic Cannabinoids: how to extract them from whole blood?

Rebecca Mastrovito from NMS has simplified the extraction of 12 novel synthetic cannabinoids using the Biotage ISOLUTE SLE+ cartridges.

Streamlined sample preparation of DoA panel in human nails using ISOLUTE® SLE+

This application note describes the sample pre-treatment and subsequent extraction of 49 drugs of abuse from human nails, prior to LC/MS analysis.

Extraction of THC and its metabolites from human nail samples using ISOLUTE® SLE+

This application note describes a procedure for sample pre-treatment and extraction of THC and its metabolites from human nail samples.

Extraction of illicit drugs and pesticides from liver tissue using ISOLUTE® SLE+

This application note describes the extraction of a broad range of analytes from liver tissue matrix prior to GC/MS analysis using ISOLUTE® SLE+.

Sample preparation for fentanyl analogs in whole blood

Fentanyl and its analogs are part of the growing opioid crisis in the United States, and there's a real need for robust sample preparation methods.

Extraction and analysis methods for fentanyl and fentanyl analogues in whole blood and urine

The results of different extraction procedures for whole blood and urine spiked with fentanyl analogues was compared to identify optimal workflows.