Alternatives to DCM/MeOH in Normal-phase Flash Chromatography

Flash chromatography using elution gradients of dichloromethane and methanol (DCM/MeOH) are the go-to purification technique for chemists trying to purify polar compound mixtures. However, chlorinated solvents such as DCM have been determined to be hazardous1
 and their use likely to be restricted by the EPA2. These issues have forced chemists to find alternative, safer solvent systems to replace commonly used DCM/MeOH.