Biotage® Carbon Cartridges

Moving from lab scale to large scale comes with a number of additional considerations. Biotage® Isolera LS, Flash 75, 150 and 400 systems are extremely tough, economically viable scale-up purification systems that have been developed for this purpose. With the Biotage approach, scaling up a number of different purification techniques is possible.  Any method developed using a Biotage lab scale cartridge can be transferred to a larger cartridge using scale-up factors. Once the development cartridge is determined and breakthrough conditions identified, the lab scale method can be replayed, providing peak elution profiles for the expected scale up run which are suitable for further optimization if needed.   A well-packed cartridge has hundreds or thousands of theoretical plates (equilibrium stages) that are available to interact with the colored product.  As a sample moves down the cartridge, it has the opportunity to interact with each plate thus increasing the equilibrium distribution of colored impurities in the stationary phase (activated carbon) and removes the impurities from the liquid phase much more efficiently and rapidly.  Each of the larger flash systems may be configured with either ‘M’ or ‘L’ cartridge capability to further increase its flexibility and range.

Key supplier to industry for over 20 years, used in numerous patents and cGMP processes.  

Purification from grams in development through to multi kilogram quantities of product for pre-clinical and commercial production campaigns.

Stationary phase silica is clean, inert and deployed to support the most demanding of purification goals. 

With lot control, an extensive QA / QC documentation package including Safety Data sheets, ISO 9001 / 14001 registration certification, BSE / TSE statement, shelf-life statements, retest guidance, storage recomendations and more, Biotage silicas are deisnged for industry and professional scale up campaigns.