Biomolecule Purification

    Experts in Biomolecule Chromatography

    Biotage offers a range of automated purification solutions in plasmid purification, protein purification and AAV purification using dual flow chromatography.

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    Antibody Biomolecules
    BIOMARK2-124 - Plasmid Card Image

    Automated Plasmid Purification

    Plasmid purification is normally a labor-intensive manual operation. The PhyPrep system offers the first automated plasmid purification system for Maxi, Mega and Giga scale preparations.

    Learn more about plasmid purification here.


    Automated Protein Purification Using PhyTip Columns

    Our PhyTip columns are available with a range of different affinity resins to accommodate most protein purification applications. Click on application and product cards below to learn more. 

    PhyTip columns are available for all major liquid handling systems, allowing their use on existing instrumentation you may already have in your lab!


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    Proven Technology

    A PhyTip column is a separation column packed in a pipette tip, that processes the sample by a technique called dual flow chromatography. This technology enable automation of purification protocols and also comes with some unique advantages such as high reproducibility and high purity of samples. 

    PhyTip columns have been used in numerous scientific publications since their launch. Learn more in the summary list of recent Scientific Journal publications.

    Download list of publications

    Product Groups

    BIOMARK002.123 - Protein Card Image
    Antibody Purification

    Affinity purification of antibodies by Protein A and other affinity medias.

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    Purification of Tagged Proteins

    Affinity purification of tagged recombinant proteins by IMAC and other affinity medias.

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    Automation Systems

    Turnkey automation systems for sample processing by PhyTip® columns.

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    Ion Exchange PhyTip® Columns

    Protein purification by ion exchange chromatography.

    mass spectrometry sample preparation
    Reversed Phase PhyTip® Columns

    Sample desalting for mass spectrometry analysis by reversed phase PhyTip® columns

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    Gel Filtration PhyTip® Columns

    High throughput desalting and buffer exchange.

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    Normal Phase PhyTip® Columns

    Glycan enrichment for oligosaccharide mapping and identification analysis of glycoproteins by normal phase PhyTip® columns.

    AAV biotage colours
    AAV PhyTip® Columns

    Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to a target.AAVs can be purified using PhyTip columns.

    Custom Packing Service
    Custom Packing Service

    Custom packing of the resin of your choice in a PhyTip® column format.

    Other Blocks in the Workflow

    Purification of 15 µg of plasmid DNA from 1 ml cell cultures. PhyTip® column technology.

    Automated endotoxin-free plasmid purification.

    Intuitive Software

    Blogs and Applications

    Learn more about advancing drug discovery in advanced therapeutics by visiting our knowledge base.

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    If you're looking to learn more about our Products and Services, please get in touch and we are more than happy to support you.


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