Biomolecule Purification

Experts in Biomolecule Chromatography

Biotage offers a range of automated purification solutions in plasmid purification, protein purification and AAV purification using dual flow chromatography.

Antibody Biomolecules

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Automated Plasmid Purification

Plasmid purification is normally a labor-intensive manual operation. The PhyPrep system offers the first automated plasmid purification system for Maxi, Mega and Giga scale preparations.

Learn more about plasmid purification here.

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Automated Protein Purification Using PhyTip Columns

Our PhyTip columns are available with a range of different affinity resins to accommodate most protein purification applications. Click on application and product cards below to learn more.

PhyTip columns are available for all major liquid handling systems, allowing their use on existing instrumentation you may already have in your lab!

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Proven Technology

A PhyTip column is a separation column packed in a pipette tip, that processes the sample by a technique called dual flow chromatography. This technology enable automation of purification protocols and also comes with some unique advantages such as high reproducibility and high purity of samples.

PhyTip columns have been used in numerous scientific publications since their launch, Learn more in the summary list of recent Scientific Journal publications.

Product Groups

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Antibody Purification

Affinity purification of antibodies by Protein A and other affinity medias.

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Purification of Tagged Proteins

Affinity purification of tagged recombinant proteins by IMAC and other affinity medias.

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Automation Systems

Turnkey automation systems for sample processing by PhyTip^® columns.

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Ion Exchange PhyTip® Columns

Protein purification by ion exchange chromatography.

mass spectrometry sample preparation

Reversed Phase PhyTip® Columns

Sample desalting for mass spectrometry analysis by reversed phase PhyTip^® columns

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Gel Filtration PhyTip® Columns

High throughput desalting and buffer exchange.

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Normal Phase PhyTip® Columns

Glycan enrichment for oligosaccharide mapping and identification analysis of glycoproteins by normal phase PhyTip^® columns.

AAV biotage colours

AAV PhyTip® Columns

Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to a target.AAVs can be purified using PhyTip columns.

Custom Packing Service

Custom Packing Service

Custom packing of the resin of your choice in a PhyTip^® column format.

Other Blocks in the Workflow

Purification of 15 µg of plasmid DNA from 1 ml cell cultures. PhyTip^® column technology.

MiniPrep Phytip Columns

Automated endotoxin-free plasmid purification.

Biotage PhyPrep Maxi Mega Giga

Intuitive Software

Blogs and Applications

Learn more about advancing drug discovery in advanced therapeutics by visiting our knowledge base.

Contact us

If you're looking to learn more about our Products and Services, please get in touch and we are more than happy to support you.

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About Biotage

Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development and diagnostics, analytical testing and water and environmental testing.

Biotage is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited.

Our customers span a broad range of market segments including pharmaceutical, biotech, diagnostic, contract research and contract manufacturers as well as clinical, forensic and academic laboratories in addition to organizations focused on food safety, clean water and environmental sustainability.

Biotage is headquartered in Uppsala in Sweden and employs over 500 people worldwide. The Group had sales of 1,566 MSEK in 2022 and our products are sold in more than 80 countries. Biotage’s share (BIOT) is listed in the Large Cap segment on the NASDAQ Stockholm.

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Biomolecule purification application page