Peptide Synthesis

The First Step of the Peptide Workflow

Biotage manufactures single and multi-channel peptide synthesizers that offer both intuitive systems that cater to those first entering the world of automated Fmoc solid phase peptide synthesis, as well as high speed parallel processing systems for the high throughput production of hundreds of peptides every week.

What is solid phase peptide synthesis?

More and more groups are exploring the utility of peptides with an ever widening variety of applications. And although peptides are getting cheaper to purchase outright, many groups are continuing to bring peptide synthesis in house. As more groups join the peptide community, there is a need to learn more about the basics of peptide synthesis.

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Peptide Synthesis Workflow - Synthesis, Purification, and Evaporation Solutions

Biotage has developed a range of tools to improve the peptide synthesis workflow, from synthesis of crude peptides through to the final purified product. These solutions make your workflow more efficient and improve the quality of peptides you synthesize. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories throughout the world.

Peptide Synthesis the Biotage way

Automated synthesizers are just part of the story. Purifying peptides as well as removing cleavage cocktails and isolating peptides from chromatographic fractions are daily activities in any peptide synthesis laboratory. Our experts can help you to choose the configuration for all steps of synthesis including purification and evaporation to best fit your demands and budget. Simply put, delivery of the final, purified peptide product can be simpler, faster, and greener with the Biotage approach to peptide synthesis.

Single Channel Peptide Synthesis

Automated Microwave Peptide Synthesizer

Single channel peptide synthesizers allow single peptides to be made sequentially. Such systems employ state of the art software and hardware to ensure intuitive operation and the highest quality results. Automation removes the possibility of human error, and microwave heating ensures high coupling efficiencies and rapid reactions.

Multi-channel Peptide Synthesis

Fully Automated Parallel Peptide Synthesizer

Multi-channel peptide synthesizers are the systems of choice for those looking to make large numbers of peptides in parallel. Offering powerful automation features and software to facilitate the synthesis of many peptides simultaneously, multi-channel peptide synthesizers are used for library synthesis and screening applications that require high throughput and productivity.

Product groups

Biotage® Initiator+ Alstra™

Biotage® Initiator+ Alstra™ is a fully automated single channel microwave peptide synthesizer with an intuitive user interface on a large touchscreen and built in flexibility for both small and large scale synthesis of peptides, peptoids, PNA and peptidomimetics.

Syro I

Syro I is a fully automated multi-channel peptide synthesizer equipped with a one arm pipetting robot. The standard system is configured with one reactor block (24 or 48 position) for use with 2, 5 and 10 ml reactor vials. Other reactor block options are available including heating block kits and Tip reactor blocks.

Syro II

Syro II is a fully automated multi-channel peptide synthesizer equipped with a two arm pipetting robot for faster washing and dispensing of reagents. The standard system is configured with two reactor blocks with other reactor block options available including heating block kits and Tip reactor blocks. This is the system of choice for those requiring the highest peptide synthesis throughput.

Green solvents for solid phase peptide synthesis

Green chemistry solutions are highly desirable. Read more to learn about greener solvent alternatives to DMF and NMP for peptide synthesis.

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A Holistic Approach to the Peptide Workflow in Drug Discovery

The study of peptides, especially for therapeutic use, has grown significantly in recent years. However, producing peptides for such research is challenging, not just in the synthesis. Biotage has developed a holistic approach to the entire peptide workflow via an automated solution, designed for dedicated peptide researchers and those new to the field.

Peptide Workflow at Red Glead Discovery

Red Glead Discovery is a pre-clinical drug discovery CRO offering a broad range of services to Life Science clients. With a focus on small molecules and peptides, their drug discovery platform ranges from medicinal chemistry and synthesis to ADME and biology. We met with Richard E. Johnsson, Ph.D., Head of Peptide Chemistry at Red Glead Discovery, Lund, Sweden, where he told us about using Biotage products in his workflow.

All resources

Other Steps in the Workflow

Biotage offer close to preparative HPLC performance in a flash format that enables more peptide to be processed in a single injection and faster with High Performance Flash Chromatography.

Flash Chromatography of Peptides

Removing Peptide Cleavage Cocktails and evaporating synthesis solvents like DMSO is no longer a problem with Biotage® V-10 Touch.

Evaporation for Peptides