ISOLUTE® PE-AX is a silica-based sorbent with a chemically bonded quaternary amine functional group. It is used for the isolation of a wide range of acidic compounds using both catch & release and scavenging protocols. ISOLUTE PE-AX is available packed into SPE cartridges for flow-through. Using the catch & release approach, acidic target compounds can be isolated from a range of reaction mixtures. ISOLUTE PE-AX cartridges can be used in a scavenging mode to remove excess acidic reagents, allowing neutral or basic compounds to pass straight through to the collection vessel.
During catch & release the media bed "catches” the compound of interest. Rinsing the cartridge with solvent removes impurities, leaving the compound of interest on the cartridge for subsequent elution by an appropriate solvent. Biotage has a range of cartridges depending on whether the product to be recovered is acidic, basic or neutral. Applications include: purification, solvent switch, concentrating & capturing and HPLC fractions.
Overall Process:
It may also be possible to retain impurities in step 3, such that the cartridge becomes a one pass, one step purification system.
Further Notes: equilibration, loading and elution solvents may be substituted. Base cartridge loading calculations on approx. 60% cartridge capacity for initial run, depending
on the product, loading may be increased further following optimization.
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
503-1000-F | ISOLUTE® PE-AX 10 g/ 70 mL | 16 | 426 USD | Add to quote/cart |
503-0200-D | ISOLUTE® PE-AX 2 g/15 mL | 20 | 167 USD | Add to quote/cart |
503-2000-F | ISOLUTE® PE-AX 20 g/ 70 mL | 16 | 853 USD | Add to quote/cart |
503-0500-E | ISOLUTE® PE-AX 5 g/25 mL | 20 | 260 USD | Add to quote/cart |
988-1000-F | ISOLUTE® PE-AX/SCX-2 10 /70 mL | 16 | 738 USD | Add to quote/cart |
988-2000-F | ISOLUTE® PE-AX/SCX-2 20 g/70 mL | 16 | 1427 USD | Add to quote/cart |
988-0500-E | ISOLUTE® PE-AX/SCX-2 5 g/25 mL | 20 | 479 USD | Add to quote/cart |
Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development, analytical testing and water and environmental testing.
Biotage is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited.
Our customers span a broad range of market segments including pharmaceutical, biotech, contract research and contract manufacturers as well as clinical, forensic and academic laboratories in addition to organizations focused on food safety, clean water and environmental sustainability.
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